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Fitzpatrick's Dermatology in General Medicine, 7e
| Part 2. Disorders Presenting in Skin and Mucous Membranes > Section 5. Inflammatory Diseases Based on Neutrophils and Eosinophils > |
Chapter 30. Regulation of the Production and Activation of Neutrophils and Eosinophils
Sections: Neutrophils, Eosinophils, References.
Excerpt:
"This section presents an overview of neutrophil biology and function
and uses a few well-characterized defects of myeloid function as
illustrations. Similar to the other components of the hematopoietic system,
the neutrophil is ultimately derived from a pluripotent hematopoietic
stem cell. The development of the myeloid stem cell is largely determined
by ambient cytokines and reflected in its surface markers, morphology,
and functional characteristics. The myeloblast is fully committed
to the neutrophil lineage and is the first morphologically distinct
cell in neutrophil development. Subsequent stages of neutrophil
development occur under the influence of granulocyte colony-stimulating
factor (G-CSF) and granulocyte-macrophage colony-stimulating factor
(GM-CSF). Four to six days are required for maturation through the
mitotic phase to the myelocyte, and 5 to 7 days more for the myelocyte
to develop into a mature neutrophil, including the metamyelocyte
and band stages, before emerging as a fully developed neutrophil.
Development of neutrophils through the myelocyte stage normally
occurs exclusively in the bone marrow, which is composed of approximately
60 percent developing neutrophils. The mature neutrophil..."
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