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Quick Medical Diagnosis & Treatment
Cryptococcosis
Sections: Key Features, Essentials of Diagnosis, General Considerations, Demographics, Clinical Findings, Symptoms and Signs, Differential Diagnosis, Diagnosis, Laboratory Tests, Imaging Studies, Diagnostic Procedures, Treatment, Medications, Acute therapy, Maintenance therapy, Therapeutic Procedures, Outcome, Complications, Prognosis, References,
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Topics Discussed: cryptococcosis; cryptococcus neoformans.
Excerpt: | |  Because of decreased efficacy initial therapy with an azole alone is not recommended for treatment of acute cryptococcal meningitis
Consequently, treatment regimens using amphotericin B should be started Amphotericin B, 0.7–1 mg/kg/d intravenously for 14 days, followed by 8 weeks of fluconazole, 400 mg orally once daily, achieves clinical response and CSF sterilization in about 70% Lipid amphotericin B preparations (eg, liposomal amphotericin B, 3–4 mg/kg/d) have equivalent efficacy to conventional amphotericin B with reduced nephrotoxicity Switch from amphotericin B to fluconazole after clinical improvement and conversion of CSF culture to negative Early addition of flucytosine, 100 mg/kg/d orally divided into four equal doses given every 6 hours, improves survival, but toxicity is..."
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