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Quick Medical Diagnosis & Treatment
Multiple Endocrine Neoplasia, Types 1 & 2
Sections: Key Features, Essentials of Diagnosis, General Considerations, Multiple endocrine neoplasia (MEN) 1 (Wermer syndrome), MEN 2A (Sipple syndrome), MEN 2B, Demographics, Clinical Findings, Symptoms and Signs, MEN 1, MEN 2A, MEN 2B, Differential Diagnosis, Diagnosis, Laboratory Tests, MEN 1, MEN 2A, MEN 2B, Treatment, Medications, MEN 1, Surgery, MEN 1, MEN 2A, Outcome, Complications, MEN 1, Prognosis, MEN 1, References,
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Topics Discussed: multiple endocrine neoplasia; multiple endocrine neoplasia type 1; multiple endocrine neoplasia type 2a; multiple endocrine neoplasia type 2b.
Excerpt: | |  Parathyroid, enteropancreatic, and pituitary tumors
Nonendocrine tumors | | – Subcutaneous lipomas – Facial angiofibromas – Collagenomas |
Mutations in the menin gene (11q13) detectable in 60–95% of cases Variants of MEN 1 occur, eg, kindreds with MEN 1 Burin have a high prevalence of prolactinomas, late-onset hyperparathyroidism, and carcinoid tumors, but rarely enteropancreatic tumors In patients with MEN 1 gastrinomas, depending on the kindred, hepatic metastases tend to be less aggressive than sporadic gastrinomas |
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