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Basic & Clinical Pharmacology, 12e
Chapter 16. Histamine, Serotonin, & the Ergot Alkaloids
Sections: Case Study, Histamine, Serotonin, & the Ergot Alkaloids: Introduction, Histamine, Histamine Receptor Antagonists, H1-Receptor Antagonists, H2-Receptor Antagonists, H3- & H4-Receptor Antagonists, Serotonin (5-Hydroxytryptamine), Serotonin Antagonists, Serotonin-Receptor Antagonists, The Ergot Alkaloids, Summary: Drugs with Actions on Histamine and Serotonin Receptors; Ergot Alkaloids, Preparations Available, References, Case Study Answer.
Topics Discussed: autonomic nervous system; drugs affecting neurotransmission; sympathomimetics; adrenergic antagonists; cholinergics; anticholinergics; ergot alkaloids; histamine.
Excerpt:"A 35-year-old man visits his family practitioner with a complaint of red, raised, itchy wheals on his arms and legs. Two days earlier, he had eaten a spicy meal at a restaurant he had not previously visited. The following morning, he woke up with the palms of his hands and the soles of his feet red and itchy. During the day, similar raised, itchy lesions appeared on his arms and legs, and some are now appearing on his trunk. He reports a similar, milder episode 2 years ago, from which he recovered without treatment. Physical examination reveals no respiratory symptoms and no evidence of pharyngeal edema. The practitioner makes a diagnosis of urticaria (hives) caused by food allergy and suggests that the patient take an over-the-counter antihistamine. The following day the patient calls saying that the antihistamine has reduced the itching slightly, but the wheals are still present and new ones are appearing. What other therapeutic measures are appropriate?..."
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