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Basic & Clinical Pharmacology, 12e
Chapter 52. Antiprotozoal Drugs
Sections: Case Study, Malaria, Amebiasis, Other Antiprotozoal Drugs, Preparations Available, References, Case Study Answer.
Topics Discussed: antiprotozoal agents; parasitic diseases; therapy of microbial diseases; bacterial, viral, fungal, and protozoal infections; therapy of parasitic infections.
Excerpt:"A 5-year-old American girl presents with a 1-week history of intermittent chills, fever, and sweats. She had returned home 2 weeks earlier after leaving the United States for the first time to spend 3 weeks with her grandparents in Nigeria. She received all standard childhood immunizations, but no additional treatment before travel, since her parents have returned to their native Nigeria frequently without medical consequences. Three days ago, the child was seen in an outpatient clinic and diagnosed with a viral syndrome. Examination reveals a lethargic child, with a temperature of 39.8°C (103.6°F) and splenomegaly. She has no skin rash or lymphadenopathy. Initial laboratory studies are remarkable for hematocrit 29.8%, platelets 45,000/mm3, creatinine 2.5 mg/dL (220  mol/L), and mildly elevated bilirubin and transaminases. A blood smear shows ring forms of Plasmodium falciparum at 1.5% parasitemia. What treatment should be started?..."
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