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Basic & Clinical Pharmacology, 12e Chapter 66. Important Drug Interactions & Their Mechanisms Sections: Important Drug Interactions & Their Mechanisms: Introduction, Predictability of Drug Interactions, References. Topics Discussed: drug interactions. Excerpt:"One of the factors that can alter the response to drugs is the concurrent administration of other drugs. There are several mechanisms by which drugs may interact, but most can be categorized as pharmacokinetic (absorption, distribution, metabolism, excretion), pharmacodynamic (additive, synergistic, or antagonistic effects), or combined interactions. The general principles of pharmacokinetics are discussed in Chapters 3 and 4; the general principles of pharmacodynamics in Chapter 2...."
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