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Harper's Illustrated Biochemistry, 29e
Chapter 46. Intracellular Traffic & Sorting of Proteins
Sections: Objectives, Biomedical Importance, Many Proteins Are Targeted by Signal Sequences to Their Correct Destinations, The Mitochondrion Both Imports & Synthesizes Proteins, Localization Signals, Importins, & Exportins Are Involved in Transport of Macromolecules in & out of the Nucleus, Proteins Imported into Peroxisomes Carry Unique Targeting Sequences, Proteins Follow Several Routes to Be Inserted into or Attached to the Membranes of the Endoplasmic Reticulum, Chaperones Are Proteins that Prevent Faulty Folding & Unproductive Interactions of Other Proteins, Accumulation of Misfolded Proteins in the Endoplasmic Reticulum Can Induce the Unfolded Protein Response (UPR), Misfolded Proteins Undergo Endoplasmic Reticulum-Associated Degradation, Ubiquitin Is a Key Molecule in Protein Degradation, Transport Vesicles Are Key Players in Intracellular Protein Traffic, The Assembly of Membranes Is Complex, Summary, References.
Topics Discussed: amino acids; intracellular protein transport; protein sorting signals.
Excerpt:"After studying this chapter, you should be able to:..."
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