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Harper's Illustrated Biochemistry, 29e Chapter 48. The Extracellular Matrix Sections: Objectives, Biomedical Importance, Collagen Type I Is Composed of a Triple Helix Structure & Forms Fibrils, Collagen Is the Most Abundant Protein in the Animal World, Elastin Confers Extensibility & Recoil on Lung, Blood Vessels & Ligaments, Marfan Syndrome Is Due to Mutations in the Gene for Fibrillin-1, a Protein Present in Microfibrils, Fibronectin Is an Important Glycoprotein Involved in Cell Adhesion & Migration, Laminin Is a Major Protein Component of Renal Glomerular & Other Basal Laminas, Proteoglycans & Glycosaminoglycans, Bone Is a Mineralized Connective Tissue, Bone Is Affected by Many Metabolic & Genetic Disorders, The Major Components of Cartilage Are Type II Collagen & Certain Proteoglycans, The Molecular Bases of the Chondrodysplasias Include Mutations in Genes Encoding Type II Collagen & Fibroblast Growth Factor Receptors, Summary, References. Topics Discussed: connective tissue; the extracellular matrix. Excerpt:"After studying this chapter, you should be able to:..."
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