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Williams Obstetrics, 23e
| Section III. Antepartum > |
Chapter 13. Prenatal Diagnosis and Fetal Therapy
Sections: Prenatal Diagnosis and Fetal Therapy: Introduction, Etiology of Birth Defects, Prenatal Diagnosis of Neural-Tube Defects, Prenatal Diagnosis of Down Syndrome and Other Aneuploidies, Fetuses at Increased Risk for Genetic Disorders, Diagnostic Techniques, Fetal Therapy, References.
Topics Discussed: fetal therapies; prenatal diagnosis.
Excerpt:"The incidence of major abnormalities apparent at birth is 2 to 3 percent. These anomalies cause a significant portion of neonatal deaths, and more than a fourth of all pediatric hospital admissions result from genetic disorders (Lee and colleagues, 2001). Prenatal diagnosis is the science of identifying structural or functional abnormalities—birth defects—in the fetus. With this information, clinicians hope to provide appropriate counseling and optimize outcome. In some cases, fetal therapy can be used to improve the intrauterine environment. Therapy may include blood product transfusion, administration of medication transplacentally or via the fetal circulation, laser or radiofrequency ablation of vascular anastomoses, amnioreduction, shunt placement, or more extensive fetal surgery...."
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