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Williams Obstetrics, 23e
| Section VII. Obstetrical Complications > |
Chapter 53. Thyroid and Other Endocrine Disorders
Sections: Thyroid and Other Endocrine Disorders: Introduction, Thyroid Disorders, Parathyroid Diseases, Adrenal Gland Disorders, Pituitary Diseases, References.
Topics Discussed: endocrinologic disorders.
Excerpt:"A variety of endocrine disorders can complicate pregnancy and vice versa. Diabetes mellitus is the most prevalent and is discussed in Chapter 52. Thyroid disorders are also common, and a number of less common endocrinopathies—for example, pheochromocytoma—can have devastating effects on pregnancy outcome. The pathogenesis of many endocrinopathies is disordered autoimmunity. And as with most organ-specific autoimmune disorders, clinical manifestations of endocrinopathies result from a complex interplay among genetic, environmental, and endogenous factors that activate the immune system against target cells (Weetman, 2004). In many cases, a nonspecific event such as a viral infection initiates an organ-specific response with subsequent immune-mediated glandular destruction. Also, studies implicating cells transferred between mother and fetus during pregnancy in development of autoimmune disease decades later represent a new investigative frontier (Muraji and associates, 2008; Rust and Bianchi, 2009)...."
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