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Quick Medical Diagnosis & Treatment
Progressive Multifocal Leukoencephalopathy (PML)
Sections: Key Features, Clinical Findings, Diagnosis, Treatment.
Excerpt: | |  A rare demyelinating CNS disorder
Caused by the reactivation of the JC virus (John Cunningham virus or JCV) | | – Virus remains latent in the kidneys, lymphoid tissues, epithelial cells, peripheral blood leukocytes, bone marrow, and possibly brain until reactivation occurs and symptoms become evident – Reactivation is usually seen in adults with | |  Impaired cell-mediated immunity, especially AIDS patients
Idiopathic CD4 lymphopenia syndrome |
– Virus reactivation is also reported among patients who have
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