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Harrison's Principles of Internal Medicine, 18e | Part 1. Introduction to Clinical Medicine > | Chapter 7. Medical Disorders During Pregnancy Sections: Medical Disorders during Pregnancy: Introduction, Hypertension, Renal Disease, Cardiac Disease, Deep Venous Thrombosis and Pulmonary Embolism, Endocrine Disorders, Obesity, Hematologic Disorders, Neurologic Disorders, Gastrointestinal and Liver Disease, Infections, Summary, Further Readings. Topics Discussed: pregnancy; pregnancy and lactation: therapeutic considerations; pregnancy complications. Excerpt:"Each year, approximately 4 million births occur in the United States, and more than 130 million births occur worldwide. A significant proportion of these are complicated by medical disorders. In the past, many medical disorders were contraindications to pregnancy. Advances in obstetrics, neonatology, obstetric anesthesiology, and medicine have increased the expectation that pregnancy will result in a positive outcome for both mother and fetus despite most of these conditions. Successful pregnancy requires important physiologic adaptations, such as a marked increase in cardiac output. Medical problems that interfere with the physiologic adaptations of pregnancy increase the risk for poor pregnancy outcome; conversely, in some instances, pregnancy may adversely impact an underlying medical disorder...."
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