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Harrison's Principles of Internal Medicine, 18e | Part 8. Infectious Diseases > Section 7. Miscellaneous Bacterial Infections > | Chapter 164. Infections Due to Mixed Anaerobic Organisms Sections: Infections Due to Mixed Anaerobic Organisms: Introduction, Further Readings. Topics Discussed: anaerobic bacterial infection. Excerpt:"Anaerobic bacteria are organisms that require reduced oxygen tension for growth, failing to grow on the surface of solid media in 10% CO2 in air. (In contrast, microaerophilic bacteria can grow in an atmosphere of 10% CO2 in air or under anaerobic or aerobic conditions, although they grow best in the presence of only a small amount of atmospheric oxygen, and facultative bacteria can grow in the presence or absence of air.) This chapter describes infections caused by nonsporulating anaerobic bacteria. Most clinically relevant anaerobes, such as Bacteroides fragilis, Prevotella melaninogenica, and Fusobacterium nucleatum, are relatively aerotolerant. Although they can survive for sustained periods in the presence of up to 28% oxygen, generally they do not multiply in this environment. A far smaller number of pathogenic anaerobic bacteria (which are also part of the normal flora) die after brief contact with oxygen, even in low concentrations.(See also Chap. 31) Anaerobic bacteria are commonly involved in infections of the mouth, head, and neck. The predominant isolates are components of the normal flora of the upper airwaysmainly the Bacteroides oralis group, pigmented Prevotella species,..."
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