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Harrison's Principles of Internal Medicine, 18e
Part 2. Cardinal Manifestations and Presentation of Diseases > Section 2. Alterations in Body Temperature >
Chapter 16. Fever and Hyperthermia
Sections:
Fever and Hyperthermia: Introduction, Fever versus Hyperthermia, Pathogenesis of Fever, Further Readings.
Topics Discussed:
fever; hyperthermia.
Excerpt:
"
Body temperature is controlled by the hypothalamus. Neurons in both the preoptic anterior hypothalamus and the posterior hypothalamus receive two kinds of signals: one from peripheral nerves that transmit information from warmth/cold receptors in the skin and the other from the temperature of the blood bathing the region. These two types of signals are integrated by the thermoregulatory center of the hypothalamus to maintain normal temperature. In a neutral temperature environment, the metabolic rate of humans produces more heat than is necessary to maintain the core body temperature in the range of 36.5–37.5°C (97.7–99.5°F)...."
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