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Harrison's Principles of Internal Medicine, 18e | Part 2. Cardinal Manifestations and Presentation of Diseases > Section 2. Alterations in Body Temperature > | Chapter 17. Fever and Rash Sections: Fever and Rash: Introduction, Classification of Rash, Further Readings. Topics Discussed: fever with rash. Excerpt:"The acutely ill patient with fever and rash often presents a diagnostic challenge for physicians. The distinctive appearance of an eruption in concert with a clinical syndrome may facilitate a prompt diagnosis and the institution of life-saving therapy or critical infection-control interventions. Representative images of many of the rashes discussed in this chapter are included in Chap. e7.A thorough history of patients with fever and rash includes the following relevant information: immune status, medications taken within the previous month, specific travel history, immunization status, exposure to domestic pets and other animals, history of animal (including arthropod) bites, existence of cardiac abnormalities, presence of prosthetic material, recent exposure to ill individuals, and exposure to sexually transmitted diseases. The history should also include the site of the onset of the rash and its direction and rate of spread...."
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