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Harrison's Principles of Internal Medicine, 18e
| Part 2. Cardinal Manifestations and Presentation of Diseases > Section 3. Nervous System Dysfunction > |
Chapter 26. Aphasia, Memory Loss, and Other Focal Cerebral Disorders
Sections: Aphasia, Memory Loss, and Other Focal Cerebral Disorders: Introduction, The Left Perisylvian Network for Language: Aphasias and Related Conditions, The Parietofrontal Network for Spatial Orientation: Neglect and Related Conditions, The Occipitotemporal Network for Face and Object Recognition: Prosopagnosia and Object Agnosia, The Limbic Network for Episodic Memory: Amnesias, The Prefrontal Network for Attention and Behavior, Caring for Patients with Deficits of Higher Cerebral Function, Further Readings.
Topics Discussed: amnesia; aphasia; memory disorders.
Excerpt:"The cerebral cortex of the human brain contains approximately 20 billion neurons spread over an area of 2.5 m2. The primary sensory areas provide an obligatory portal for the entry of sensory information into cortical circuitry, and the primary motor areas provide a final common pathway for coordinating complex motor acts. The primary sensory and motor areas constitute 10% of the cerebral cortex. The rest is subsumed by modality-selective, heteromodal, paralimbic, and limbic areas collectively known as the association cortex (Fig. 26-1). The association cortex mediates the integrative processes that subserve cognition, emotion, and behavior. A systematic testing of these mental functions is necessary for the effective clinical assessment of the association cortex and its diseases...."
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