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Harrison's Principles of Internal Medicine, 18e
| Part 2. Cardinal Manifestations and Presentation of Diseases > Section 7. Alterations in Renal and Urinary Tract Function > |
Chapter 46. Hypercalcemia and Hypocalcemia
Sections: Hypercalcemia and Hypocalcemia: Introduction, Hypercalcemia, Hypocalcemia, Further Readings.
Topics Discussed: disorders of calcium and phosphorus homeostasis; hypercalcemia; hypocalcemia.
Excerpt:"The calcium ion plays a critical role in normal cellular function and signaling, regulating diverse physiologic processes such as neuromuscular signaling, cardiac contractility, hormone secretion, and blood coagulation. Thus, extracellular calcium concentrations are maintained within an exquisitely narrow range through a series of feedback mechanisms that involve parathyroid hormone (PTH) and the active vitamin D metabolite 1,25-dihydroxyvitmin D [1,25(OH)2D]. These feedback mechanisms are orchestrated by integrating signals between the parathyroid glands, kidney, intestine, and bone (Fig. 46-1; Chap. 352)...."
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