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Harrison's Principles of Internal Medicine, 18e
| Part 2. Cardinal Manifestations and Presentation of Diseases > Section 7. Alterations in Renal and Urinary Tract Function > |
Chapter 47. Acidosis and Alkalosis
Sections: Normal Acid-Base Homeostasis, Diagnosis of General Types of Disturbances, Metabolic Acidosis, Metabolic Alkalosis, Respiratory Acidosis, Respiratory Alkalosis, Further Readings.
Topics Discussed: acid-base disorders; acidosis; alkalosis.
Excerpt:"Systemic arterial pH is maintained between 7.35 and 7.45 by extracellular and intracellular chemical buffering together with respiratory and renal regulatory mechanisms. The control of arterial CO2 tension (Paco2) by the central nervous system (CNS) and respiratory systems and the control of the plasma bicarbonate by the kidneys stabilize the arterial pH by excretion or retention of acid or alkali. The metabolic and respiratory components that regulate systemic pH are described by the Henderson-Hasselbalch equation:..."
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