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Harrison's Principles of Internal Medicine, 18e
| Part 3. Genes, the Environment, and Disease > |
Chapter 63. The Practice of Genetics in Clinical Medicine
Sections: Applications of Molecular Genetics in Clinical Medicine, Common Adult-Onset Genetic Disorders, Genetic Testing for Adult-Onset Disorders, Genetic Counseling and Education, Therapeutic Interventions Based on Genetic Risk for Disease, Further Readings.
Topics Discussed: clinical medicine; genetics, molecular.
Excerpt:"The field of medical genetics has traditionally focused on chromosomal abnormalities (Chap. 62) and Mendelian disorders (Chap. 61). However, there is genetic susceptibility to many common adult-onset diseases, including atherosclerosis, cardiac disorders, asthma, hypertension, autoimmune diseases, diabetes mellitus, macular degeneration, Alzheimer's disease, psychiatric disorders, and many forms of cancer. Genetic contributions to these common disorders involve more than the ultimate expression of the condition; these genes can also influence the severity of illness, progression of disease, and effect of treatment...."
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