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Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 9. Spirochetal Diseases > |
Chapter 169. Syphilis
Sections: Definition, Etiology, Transmission and Epidemiology, Natural Course and Pathogenesis of Untreated Syphilis, Clinical Manifestations, Laboratory Examinations, Immunity to Syphilis, Further Readings.
Topics Discussed: syphilis.
Excerpt:"Syphilis, a chronic systemic infection caused by Treponema pallidum subspecies pallidum, is usually sexually transmitted and is characterized by episodes of active disease interrupted by periods of latency. After an incubation period averaging 2–6 weeks, a primary lesion appears, often associated with regional lymphadenopathy. The secondary stage, associated with generalized mucocutaneous lesions and generalized lymphadenopathy, is followed by a latent period of subclinical infection lasting years or decades. Central nervous system (CNS) involvement may occur early in infection and may be symptomatic or asymptomatic. In about one-third of untreated cases, the tertiary stage appears, characterized by progressive destructive mucocutaneous, musculoskeletal, or parenchymal lesions; aortitis; or late CNS manifestations...."
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