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Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 11. Viral Diseases. General Considerations > |
Chapter 178. Antiviral Chemotherapy, Excluding Antiretroviral Drugs
Sections: Antiviral Chemotherapy, Excluding Antiretroviral Drugs: Introduction, Antiviral Drugs Active Against Respiratory Infections, Antiviral Drugs Active Against Herpesvirus Infections, Antiviral Drugs Active Against Hepatitis Viruses, Interferons, Protease Inhibitors, Further Readings.
Topics Discussed: antiviral agents; pharmacotherapy of infectious diseases; therapy of microbial diseases; bacterial, viral, fungal, and protozoal infections; virus diseases.
Excerpt:"The field of antiviral therapy—both the number of antiviral drugs and our understanding of their optimal use—historically has lagged behind that of antibacterial drug treatment, but significant progress has been made in recent years on new drugs for several viral infections. The development of antiviral drugs poses several challenges. Viruses replicate intracellularly and often employ host cell enzymes, macromolecules, and organelles for synthesis of viral particles. Therefore, useful antiviral compounds must discriminate between host and viral functions with a high degree of specificity; agents without such selectivity are likely to be too toxic for clinical use...."
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