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Harrison's Principles of Internal Medicine, 18e
| Part 10. Disorders of the Cardiovascular System > Section 5. Vascular Disease > |
Chapter 243. Ischemic Heart Disease
Sections: Ischemic Heart Disease: Introduction, Coronary Atherosclerosis, Stable Angina Pectoris, Coronary Revascularization, Asymptomatic (Silent) Ischemia, Further Readings.
Topics Discussed: ischemic heart disease; ischemic heart disease, chronic.
Excerpt:"Ischemic heart disease (IHD) is a condition in which there is an inadequate supply of blood and oxygen to a portion of the myocardium; it typically occurs when there is an imbalance between myocardial oxygen supply and demand. The most common cause of myocardial ischemia is atherosclerotic disease of an epicardial coronary artery (or arteries) sufficient to cause a regional reduction in myocardial blood flow and inadequate perfusion of the myocardium supplied by the involved coronary artery. Chapter 241 deals with the development and treatment of atherosclerosis. This chapter focuses on the chronic manifestations and treatment of ischemic heart disease. The following chapters address the acute phases of this disease.IHD causes more deaths and disability and incurs greater economic costs than any other illness in the developed world. IHD is the most common, serious, chronic, life-threatening illness in the United States, where 13 million persons have IHD, >6 million have angina pectoris, and >7 million have sustained a myocardial infarction. Genetic factors, a high-fat and energy-rich diet, smoking, and a sedentary lifestyle are associated with the emergence of IHD (Chap. 241). In the United States and Western Europe, it is growing among low-income groups,..."
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