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Harrison's Principles of Internal Medicine, 18e | Part 10. Disorders of the Cardiovascular System > Section 5. Vascular DiseaseĀ > | Chapter 244. Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction Sections: Unstable Angina and INon-ST-Segment Elevation Myocardial Infarction: Introduction, Further Readings. Topics Discussed: acute coronary syndromes; non-st-segment elevation mi; unstable angina. Excerpt:"Patients with ischemic heart disease fall into two large groups: patients with chronic coronary artery disease (CAD) who most commonly present with stable angina (Chap. 243) and patients with acute coronary syndromes (ACSs). The latter group, in turn, is composed of patients with acute myocardial infarction (MI) with ST-segment elevation on their presenting electrocardiogram (ECG) (STEMI; Chap. 245) and those with unstable angina (UA) and non-ST-segment elevation MI (UA/NSTEMI; Fig. 245-1). Every year in the United States, approximately 1 million patients are admitted to hospitals with UA/NSTEMI as compared with 300,000 patients with acute STEMI. The relative incidence of UA/NSTEMI compared to STEMI appears to be increasing. More than one-third of patients with UA/NSTEMI are women, while less than one-fourth of patients with STEMI are women.The diagnosis of UA is based largely on the clinical presentation. Stable angina pectoris is characterized by chest or arm discomfort that may not be described as pain but is reproducibly associated with physical exertion or stress and is relieved within 510 minutes by rest and/or sublingual nitroglycerin (Chaps. 12 and 343). UA is defined as angina pectoris or equivalent ischemic..."
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