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Harrison's Principles of Internal Medicine, 18e
| Part 13. Disorders of the Kidney and Urinary Tract > |
Chapter e35. Interstitial Cystitis/Painful Bladder Syndrome
Sections: Interstitial Cystitis/Painful Bladder Syndrome: Introduction, Treatment: Interstitial Cystitis/Painful Bladder Syndrome, Further Readings.
Topics Discussed: bladder pain; cystitis, interstitial.
Excerpt:"Most clinicians with outpatient practices see undiagnosed cases of interstitial cystitis/painful bladder syndrome (IC/PBS). This chronic condition is characterized by pain perceived to be from the urinary bladder, urinary urgency and frequency, and nocturia. As currently diagnosed, the great majority of cases occur in women. Symptoms wax and wane for months or years or possibly even for the patient's lifetime. The spectrum of symptom intensity is broad. The pain can be excruciating, urgency can be distressing, frequency can be up to 60 times per 24 h, and nocturia can be causative of sleep deprivation. These symptoms can be disabling in terms of daily activities, work schedules, and personal relationships; patients with IC/PBS report less life satisfaction than do those with end-stage renal disease. The etiology of IC/PBS is unknown. It is not a new disease, having first been described in the late nineteenth century in a patient with the symptoms described above and a single ulcer visible on cystoscopy (now called Hunner's ulcer after the urologist who first reported it). Over the ensuing decades, it became clear that many patients with similar symptoms had no ulcer. It is now appreciated that  10% of patients with IC/PBS have a..."
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