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Harrison's Principles of Internal Medicine, 18e
| Part 4. Regenerative Medicine > |
Chapter 66. Hematopoietic Stem Cells
Sections: Hematopoietic Stem Cells: Introduction, Cardinal Functions of Hematopoietic Stem Cells, Cancer Is Similar to an Organ with Self-Renewing Capacity, What Else Can Hematopoietic Stem Cells Do?, Further Readings.
Topics Discussed: hematopoietic stem cell transplantation; hematopoietic stem cells.
Excerpt:"All of the cell types in the peripheral blood and some cells in every tissue of the body are derived from hematopoietic (hemo: blood; poiesis: creation) stem cells. If the hematopoietic stem cell is damaged and can no longer function (e.g., due to a nuclear accident), a person would survive 2–4 weeks in the absence of extraordinary support measures. With the clinical use of hematopoietic stem cells, tens of thousands of lives are saved each year (Chap. 114). Stem cells produce tens of billions of blood cells daily from a stem cell pool that is estimated to be only in the hundreds of thousands. How stem cells do this, how they persist for many decades despite the production demands, and how they may be better used in clinical care are important issues in medicine...."
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