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Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 1. Neoplastic Disorders > |
Chapter 83. Cancer Genetics
Sections: Cancer Is a Genetic Disease, Historical Perspective, The Clonal Origin and Multistep Nature of Cancer, Two Types of Cancer Genes: Oncogenes and Tumor-Suppressor Genes, Oncogenes in Human Cancer, Mechanisms of Oncogene Activation, Chromosomal Instability in Solid Tumors, Tumor-Suppressor Gene Inactivation in Cancer, Familial Cancer Syndromes, Genetic Testing for Familial Cancer, MicroRNAs and Cancer, Viruses in Human Cancer, Gene Expression in Cancer, Genomewide Mutational Profiling in Cancer, Personalized Cancer Treatment Based on Molecular Profiles, The Future, Further Readings.
Topics Discussed: cancer; pathophysiology of neoplasia; the genetics of cancer.
Excerpt:"Cancer arises through a series of somatic alterations in DNA that result in unrestrained cellular proliferation. Most of these alterations involve actual sequence changes in DNA (i.e., mutations). They may originate as a consequence of random replication errors, exposure to carcinogens (e.g., radiation), or faulty DNA repair processes. While most cancers arise sporadically, familial clustering of cancers occurs in certain families that carry a germline mutation in a cancer gene...."
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