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Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 1. Neoplastic Disorders > |
Chapter 93. Pancreatic Cancer
Sections: Pancreatic Cancer: Introduction, Epidemiology, Risk Factors, Genetic Considerations, Screening and Early Detection, Clinical Features, Diagnosis, Staging, Future Directions, Further Readings.
Topics Discussed: pancreatic cancer; pathophysiology of disorders of the exocrine pancreas; pathophysiology of neoplasia.
Excerpt:"Pancreatic cancer is the fourth leading cause of cancer death in the United States and is associated with a poor prognosis. Endocrine tumors affecting the pancreas are discussed in Chap. 350. Infiltrating ductal adenocarcinomas, the subject of this chapter, account for the vast majority of cases and arise most frequently in the head of pancreas. At the time of diagnosis 85–90% of patients have inoperable or metastatic disease, which is reflected in the 5-year survival rate of only 5% for all stages combined. An improved 5-year survival of up to 20% may be achieved when the tumor is detected at an early stage and when complete surgical resection is accomplished...."
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