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Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 1. Neoplastic Disorders > |
Chapter 101. Paraneoplastic Neurologic Syndromes
Sections: Paraneoplastic Neurologic Syndromes: Introduction, Pathogenesis, Specific Paraneoplastic Neurologic Syndromes, Further Readings.
Topics Discussed: paraneoplastic syndromes, nervous system; pathophysiology of neoplasia; pathophysiology of nervous system disorders.
Excerpt:"Paraneoplastic neurologic disorders (PNDs) are cancer-related syndromes that can affect any part of the nervous system (Table 101–1). They are caused by mechanisms other than metastasis or by any of the complications of cancer such as coagulopathy, stroke, metabolic and nutritional conditions, infections, and side effects of cancer therapy. In 60% of patients the neurologic symptoms precede the cancer diagnosis. Clinically disabling PNDs occur in 0.5–1% of all cancer patients, but they affect 2–3% of patients with neuroblastoma or small cell lung cancer (SCLC) and 30–50% of patients with thymoma or sclerotic myeloma...."
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