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Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 1. Neoplastic Disorders > |
Chapter 102. Late Consequences of Cancer and Its Treatment
Sections: Late Consequences of Cancer and Its Treatment: Introduction, Cardiovascular Dysfunction, Pulmonary Dysfunction, Neurologic Dysfunction, Hepatic Dysfunction, Renal/Bladder Dysfunction, Reproductive and Endocrine Dysfunction, Ocular Complications, Oral Complications, Raynaud's Phenomenon, Second Malignancies, Recommendations for Follow-Up, Outlook, Further Readings.
Topics Discussed: cancer; cancer survivorship; cancer treatment and chemotherapy.
Excerpt:"Over 10 million Americans are cancer survivors. The vast majority of these people will bear some mark of their cancer and/or its treatment, and a large proportion will experience long-term consequences that include medical problems, psychosocial dysfunction, economic hardship, sexual dysfunction, and discrimination in employment and insurance. Many of these problems are directly related to cancer treatment. As patients with more types of malignancies survive longer, the biologic toll that very imperfect therapies take in terms of morbidity and mortality rates is being recognized increasingly. These consequences of therapy confront the patients and the cancer specialists and general internists who manage them every day. Although long-term survivors of childhood leukemias, Hodgkin's lymphoma, and testicular cancer have increased knowledge about the consequences of cancer treatment, researchers and physicians keep learning more as patients survive longer with newer therapies. The pace of the development of therapies that mitigate treatment-related consequences has been slow, partly due to an understandable aversion to altering regimens that work and partly due to a lack of new, effective, less toxic therapeutic agents with less "collateral damage" to replace known agents with known toxicities...."
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