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Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 2. Hematopoietic Disorders > |
Chapter 104. Disorders of Hemoglobin
Sections: Disorders of Hemoglobin: Introduction, Properties of the Human Hemoglobins, Classification of Hemoglobinopathies, Detection and Characterization of Hemoglobinopathies—General Methods, Structurally Abnormal Hemoglobins, Thalassemia Syndromes, Thalassemic Structural Variants, Experimental Therapies, Aplastic and Hypoplastic Crisis in Patients with Hemoglobinopathies, Further Readings.
Topics Discussed: hemoglobinopathies; pathophysiology of blood disorders; red and white blood cells.
Excerpt:"Hemoglobin is critical for normal oxygen delivery to tissues; it is also present in erythrocytes in such high concentrations that it can alter red cell shape, deformability, and viscosity. Hemoglobinopathies are disorders affecting the structure, function, or production of hemoglobin. These conditions are usually inherited and range in severity from asymptomatic laboratory abnormalities to death in utero. Different forms may present as hemolytic anemia, erythrocytosis, cyanosis, or vasoocclusive stigmata...."
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