|
Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 2. Hematopoietic Disorders > |
Chapter 105. Megaloblastic Anemias
Sections: Megaloblastic Anemias: Introduction, Cobalamin, Folate, Biochemical Basis of Megaloblastic Anemia, Clinical Features, Hematologic Findings, Causes of Cobalamin Deficiency, Causes of Folate Deficiency, Diagnosis of Cobalamin and Folate Deficiencies, Megaloblastic Anemia Not Due to Cobalamin or Folate Deficiency or Altered Metabolism, Further Readings.
Topics Discussed: anemias; megaloblastic anemia; pathophysiology of blood disorders; red and white blood cells.
Excerpt:"The megaloblastic anemias are a group of disorders characterized by the presence of distinctive morphologic appearances of the developing red cells in the bone marrow. The marrow is usually cellular and the anemia is based on ineffective erythropoiesis. The cause is usually a deficiency of either cobalamin (vitamin B12) or folate, but megaloblastic anemia may occur because of genetic or acquired abnormalities that affect the metabolism of these vitamins or because of defects in DNA synthesis not related to cobalamin or folate (Table 105–1). Cobalamin and folate absorption and metabolism are described next, followed by the biochemical basis, clinical and laboratory features, causes, and treatment of megaloblastic anemia...."
The content above is only an excerpt.
For full access, log into an existing user account below,
purchase an annual subscription, or
purchase a short-term subscription to the complete website.
|
|
|
|
Or
|
|
|
|