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Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 2. Hematopoietic Disorders > |
Chapter 114. Hematopoietic Cell Transplantation
Sections: Hematopoietic Cell Transplantation: Introduction, The Hematopoietic Stem Cell, Categories of Hematopoietic Cell Transplantation, The Transplant Preparative Regimen, Treatment of Specific Diseases Using Hematopoietic Cell Transplantation, Further Readings.
Topics Discussed: hematopoietic stem cell transplantation; immunity in transplantation; pharmacotherapy of hematologic disorders; therapy of neoplastic diseases.
Excerpt:"Bone marrow transplantation was the original term used to describe the collection and transplantation of hematopoietic stem cells, but with the demonstration that the peripheral blood and umbilical cord blood are also useful sources of stem cells, hematopoietic cell transplantation has become the preferred generic term for this process. The procedure is usually carried out for one of two purposes: (1) to replace an abnormal but nonmalignant lymphohematopoietic system with one from a normal donor or (2) to treat malignancy by allowing the administration of higher doses of myelosuppressive therapy than would otherwise be possible. The use of hematopoietic cell transplantation has been increasing, both because of its efficacy in selected diseases and because of increasing availability of donors. The Center for International Blood and Marrow Transplant Research (http://www.cibmtr.org) estimates that about 65,000 transplants are performed each year...."
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