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Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 5. Diseases Caused by Gram-Positive Bacteria > |
Chapter 139. Listeria Monocytogenes Infections
Sections: Listeria Monocytogenes Infections: Introduction, Further Readings.
Topics Discussed: listeria monocytogenes; listeriosis.
Excerpt:"Listeria monocytogenes is a food-borne pathogen that can cause serious infections, particularly in pregnant women and immunocompromised individuals. A ubiquitous saprophytic environmental bacterium, L. monocytogenes is also a facultative intracellular pathogen with a broad host range. Humans are probably accidental hosts for this microorganism. L. monocytogenes is of interest not only to clinicians but also to basic scientists as a model intracellular pathogen that is used to study basic mechanisms of microbial pathogenesis and host immunity.L. monocytogenes is a facultatively anaerobic, nonsporulating, gram-positive rod that grows over a broad temperature range, including refrigeration temperatures. This organism is motile during growth at low temperatures but much less so at 37°C. The vast majority of cases of human listerial disease can be traced to serotypes 1/2a, 1/2b, and 4. L. monocytogenes is weakly  -hemolytic on blood agar, and (as detailed below) its -hemolysin is an essential determinant of its pathogenicity.Appreciated only since the outbreaks of the late 1980s, listerial gastroenteritis..."
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