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Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 5. Diseases Caused by Gram-Positive Bacteria > |
Chapter 142. Gas Gangrene and Other Clostridial Infections
Sections: Gas Gangrene and Other Clostridial Infections: Introduction, Etiologic Agent, Epidemiology and Transmission, Clinical Syndromes, Further Readings.
Topics Discussed: clostridial infection; gas gangrene.
Excerpt:"The genus Clostridium encompasses more than 60 species that may be commensals of the gut microflora or may cause a variety of infections in humans and animals through the production of a plethora of proteinaceous exotoxins. C. tetani and C. botulinum, for example, cause specific clinical disease by elaborating single but highly potent toxins. In contrast, C. perfringens and C. septicum cause aggressive necrotizing infections that are attributable to multiple toxins, including bacterial proteases, phospholipases, and cytotoxins...."
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