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Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 6. Diseases Caused by Gram-Negative Bacteria > |
Chapter 150. Acinetobacter Infections
Sections: Acinetobacter Infections: Introduction, Further Readings.
Topics Discussed: acinetobacter infections.
Excerpt:"Infections with bacteria of the genus Acinetobacter have become a significant problem worldwide. Acinetobacter baumannii is particularly formidable because of its propensity to acquire antibiotic resistance determinants. Outbreaks of infection caused by strains of A. baumannii resistant to multiple antibiotic classes, including carbapenems, are a serious concern in many specialized hospital units, including intensive care units (ICUs). The foremost implication of infection with carbapenem-resistant A. baumannii is the need to use "last-line" antibiotics such as colistin, polymyxin B, or tigecycline; these options have the potential to render these bacteria resistant to all available antibiotics.Acinetobacter species are oxidase-negative, nonmotile, nonfermenting, short gram-negative bacilli that grow well at 37° C in aerobic conditions on a range of laboratory media (e.g., blood agar). Some species may not grow on MacConkey agar. Differentiation of Acinetobacter species is difficult with the means typically available to most clinical microbiology laboratories, including commercial semiautomated identification systems. DNA-DNA hybridization is a method used for speciation in reference laboratories...."
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