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Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 6. Diseases Caused by Gram-Negative Bacteria > |
Chapter 151. Helicobacter pylori Infections
Sections: Helicobacter Pylori Infections: Introduction, Further Readings.
Topics Discussed: helicobacter infections.
Excerpt:"Helicobacter pylori colonizes the stomachs of  50% of the world's human population throughout their lifetimes. Colonization with this organism is the main risk factor for peptic ulceration (Chap. 293) as well as for gastric adenocarcinoma and gastric MALT (mucosa-associated lymphoid tissue) lymphoma (Chap. 91). Treatment for H. pylori has revolutionized the management of peptic ulcer disease, providing a permanent cure in most cases. Such treatment also represents first-line therapy for patients with low-grade gastric MALT lymphoma. Treatment of H. pylori is of no benefit in the treatment of gastric adenocarcinoma, but prevention of H. pylori colonization could potentially prevent gastric malignancy and peptic ulceration. In contrast, increasing evidence indicates that lifelong H. pylori colonization may offer some protection against complications of gastroesophageal reflux disease (GERD), including esophageal adenocarcinoma. Recent research has focused on whether H. pylori colonization is a risk factor for some extragastric diseases and whether it is protective against some recently emergent medical problems, such as asthma and obesity...."
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