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Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 12. Infections Due to DNA Viruses > |
Chapter 179. Herpes Simplex Virus Infections
Sections: Herpes Simplex Virus Infections: Introduction, Further Readings.
Topics Discussed: herpes simplex infection; simplexvirus.
Excerpt:"Herpes simplex viruses (HSV-1, HSV-2; Herpesvirus hominis) produce a variety of infections involving mucocutaneous surfaces, the central nervous system (CNS), and—on occasion—visceral organs. Prompt recognition and treatment reduce the morbidity and mortality rates associated with HSV infections.Gingivostomatitis and pharyngitis are the most common clinical manifestations of first-episode HSV-1 infection, while recurrent herpes labialis is the most common clinical manifestation of reactivation HSV-1 infection. HSV pharyngitis and gingivostomatitis usually result from primary infection and are most commonly seen among children and young adults. Clinical symptoms and signs, which include fever, malaise, myalgias, inability to eat, irritability, and cervical adenopathy, may last 3–14 days. Lesions may involve the hard and soft palate, gingiva, tongue, lip, and facial area. HSV-1 or HSV-2 infection of the pharynx usually results in exudative or ulcerative lesions of the posterior pharynx and/or tonsillar pillars. Lesions of the tongue, buccal mucosa, or gingiva may occur later in the course in one-third of cases. Fever lasting 2–7 days and cervical adenopathy are common. It can be difficult to differentiate HSV pharyngitis clinically from..."
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