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Harrison's Principles of Internal Medicine, 18e | Part 10. Disorders of the Cardiovascular System > Section 4. Disorders of the Heart > | Chapter 236. Congenital Heart Disease in the Adult Sections: Congenital Heart Disease in the Adult: Introduction, Cardiac Development, Specific Cardiac Defects, Further Readings. Topics Discussed: congenital heart disease. Excerpt:"A little over a hundred years ago, Sir William Osler, in his classic textbook The Principles and Practice of Medicine (New York, Appleton & Co, 1892, pp 659663), devoted only five pages to "Congenital Affections of the Heart," with the first sentence declaring, that "[t]hese [disorders] have only limited clinical interest, as in a large proportion of cases the anomaly is not compatible with life, and in others nothing can be done to remedy the defect or even to relieve symptoms." Fortunately, in the intervening century, considerable progress has been made in understanding the basis for these disorders and their effective treatment...."
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