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Harrison's Principles of Internal Medicine, 18e
| Part 11. Disorders of the Respiratory System > Section 2. Diseases of the Respiratory System > |
Chapter 266. Lung Transplantation
Sections: Lung Transplantation: Introduction, Further Readings.
Topics Discussed: lung transplantation; solid-organ transplantation.
Excerpt:"Lung transplantation is a therapeutic consideration for many patients with nonmalignant end-stage lung disease, and it prolongs survival and improves quality of life in appropriately selected recipients. Since 1985 more than 25,000 procedures have been recorded worldwide, and ~2200 transplants have been reported annually in recent years.The indications span the gamut of lung diseases. The most common indications in the last few years have been chronic obstructive pulmonary disease (COPD), ~30%; idiopathic pulmonary fibrosis (IPF), ~30%; cystic fibrosis (CF), ~15%;  1-antitrypsin deficiency emphysema, ~3%; and idiopathic pulmonary arterial hypertension (IPAH), ~2%. Other diseases have accounted for the balance of primary indications, and retransplantation has accounted for ~4% of procedures.Major registries publish survival (Table 266-2) and other outcomes annually (www.ishlt.org; www.ustransplant.org). In the international registry, survival half-life for the main indications is in the range of 4–6 years; however, age and transplant procedure have a significant impact on outcome. For recipients 18–59 years of age, the survival half-life is 5–6 years,..."
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