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Harrison's Principles of Internal Medicine, 18e
| Part 13. Disorders of the Kidney and Urinary Tract > |
Chapter 278. Adaption of the Kidney to Renal Injury
Sections: Adaption of the Kidney to Renal Injury: Introduction, Common Mechanisms of Progressive Renal Disease, Response to Reduction in Numbers of Functioning Nephrons, Tubular Function in Chronic Renal Failure, Modifiers Influencing the Progression of Renal Disease, Further Readings.
Topics Discussed: kidney; renal trauma.
Excerpt:"The size of a kidney and the total number of nephrons formed late in embryologic development depend on the degree to which the ureteric bud undergoes branching morphogenesis. Humans have between 225,000 and 900,000 nephrons in each kidney, a number that mathematically hinges on whether ureteric branching goes to completion or is terminated prematurely by one or two cycles. Although the signaling mechanisms regulating cycle number are incompletely understood, these final rounds of branching likely determine how well the kidney will adapt to the physiologic demands of blood pressure and body size, various environmental stresses, or unwanted inflammation leading to chronic renal failure...."
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