|
Harrison's Principles of Internal Medicine, 18e
| Part 13. Disorders of the Kidney and Urinary Tract > |
Chapter 283. Glomerular Diseases
Sections: Glomerular Diseases: Introduction, Pathogenesis of Glomerular Disease, Progression of Glomerular Disease, Acute Nephritic Syndromes, Nephrotic Syndrome, Pulmonary-Renal Syndromes, Basement Membrane Syndromes, Glomerular-Vascular Syndromes, Infectious Disease–Associated Syndromes, Further Readings.
Topics Discussed: glomerulonephritis; renal glomerular disease.
Excerpt:"Two human kidneys harbor nearly 1.8 million glomerular capillary tufts. Each glomerular tuft resides within Bowman's space. The capsule circumscribing this space is lined by parietal epithelial cells that transition into tubular epithelia forming the proximal nephron or migrate into the tuft to replenish podocytes. The glomerular capillary tuft derives from an afferent arteriole that forms a branching capillary bed embedded in mesangial matrix (Fig. 283-1). This capillary network funnels into an efferent arteriole, which passes filtered blood into cortical peritubular capillaries or medullary vasa recta that supply and exchange with a folded tubular architecture. Hence the glomerular capillary tuft, fed and drained by arterioles, represents an arteriolar portal system. Fenestrated endothelial cells resting on a glomerular basement membrane (GBM) line glomerular capillaries. Delicate foot processes extending from epithelial podocytes shroud the outer surface of these capillaries, and podocytes interconnect to each other by slit-pore membranes forming a selective filtration barrier...."
The content above is only an excerpt.
For full access, log into an existing user account below,
purchase an annual subscription, or
purchase a short-term subscription to the complete website.
|
|
|
|
Or
|
|
|
|