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Harrison's Principles of Internal Medicine, 18e
| Part 13. Disorders of the Kidney and Urinary Tract > |
Chapter 289. Urinary Tract Obstruction
Sections: Urinary Tract Obstruction: Introduction, Etiology, Clinical Features and Pathophysiology, Diagnosis, Prognosis, Postobstructive Diuresis, Further Readings.
Topics Discussed: urinary tract obstruction.
Excerpt:"Obstruction to the flow of urine, with attendant stasis and elevation in urinary tract pressure, impairs renal and urinary conduit functions and is a common cause of acute and chronic kidney disease (obstructive nephropathy). With early relief of obstruction, the defects in function usually disappear completely. However, chronic obstruction may produce permanent loss of renal mass (renal atrophy) and excretory capability, as well as enhanced susceptibility to local infection and stone formation. Early diagnosis and prompt therapy are, therefore, essential to minimize the otherwise devastating effects of obstruction on kidney structure and function...."
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