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Harrison's Principles of Internal Medicine, 18e | Part 14. Disorders of the Gastrointestinal System > Section 1. Disorders of the Alimentary Tract > | Chapter 292. Diseases of the Esophagus Sections: Esophageal Structure and Function, Symptoms of Esophageal Disease, Diagnostic Studies, Structural Disorders, Congenital Anomalies, Esophageal Motility Disorders, Gastroesophageal Reflux Disease (GERD), Eosinophilic Esophagitis, Infectious Esophagitis, Mechanical Trauma and Iatrogenic Injury, Esophageal Manifestations of Systemic Disease, Further Readings. Topics Discussed: esophageal disease. Excerpt:"The esophagus is a hollow muscular tube coursing through the posterior mediastinum joining the hypopharynx to the stomach with a sphincter at each end. It functions to transport food and fluid between these ends, otherwise remaining empty. The physiology of swallowing, esophageal motility, and oral and pharyngeal dysphagia are described in Chap. 38. Esophageal diseases can be manifested by impaired function or pain. Key functional impairments are swallowing disorders and excessive gastroesophageal reflux. Pain, sometimes indistinguishable from cardiac chest pain, can result from inflammation, infection, dysmotility, or neoplasm...."
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