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Harrison's Principles of Internal Medicine, 18e
| Part 15. Disorders of the Joints and Adjacent Tissues > Section 2. Disorders of Immune-Mediated Injury > |
Chapter 317. Allergies, Anaphylaxis, and Systemic Mastocytosis
Sections: Allergies, Anaphylaxis, and Systemic Mastocytosis: Introduction, Anaphylaxis, Urticaria and Angioedema, Pathophysiology and Manifestations, Diagnosis, Systemic Mastocytosis, Allergic Rhinitis, Further Readings.
Topics Discussed: hypersensitivity.
Excerpt:"The term atopic allergy implies a familial tendency to manifest such conditions as asthma, rhinitis, urticaria, and eczematous dermatitis (atopic dermatitis) alone or in combination, and in association with the presence of IgE. However, individuals without an atopic background may also develop hypersensitivity reactions, particularly urticaria and anaphylaxis, associated with the presence of IgE. Inasmuch as the mast cell is the key effector cell of the biologic response in allergic rhinitis, urticaria, anaphylaxis, and systemic mastocytosis, its developmental biology, activation pathway, product profile, and target tissues will be considered in the introduction to these clinical disorders...."
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