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Harrison's Principles of Internal Medicine, 18e
| Part 15. Disorders of the Joints and Adjacent Tissues > Section 2. Disorders of Immune-Mediated Injury > |
Chapter 319. Systemic Lupus Erythematosus
Sections: Definition and Prevalence, Pathogenesis and Etiology, Pathology, Diagnosis, Interpretation of Clinical Manifestations, Laboratory Tests, Patient Outcomes, Prognosis, and Survival, Drug-Induced Lupus, Further Readings.
Topics Discussed: systemic lupus erythematosus; systemic lupus erythematosus and other collagen-vascular diseases.
Excerpt:"Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage initially mediated by tissue-binding autoantibodies and immune complexes. In most patients, autoantibodies are present for a few years before the first clinical symptom appears; clinical manifestations are heterogeneous. Ninety percent of patients at diagnosis are women of childbearing years; people of all genders, ages, and ethnic groups are susceptible. Prevalence of SLE in the United States is 10 to 400 per 100,000 depending on race and gender; highest prevalence is in black women and lowest is in white men...."
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