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Harrison's Principles of Internal Medicine, 18e
| Part 15. Disorders of the Joints and Adjacent Tissues > Section 2. Disorders of Immune-Mediated Injury > |
Chapter 320. Antiphospholipid Antibody Syndrome
Sections: Definition, Epidemiology, Pathogenesis, Clinical Manifestations and Laboratory Findings, Diagnosis and Differential Diagnosis, Further Readings.
Topics Discussed: antiphospholipid syndrome.
Excerpt:"Antiphospholipid antibody syndrome (APS) is an autoantibody-mediated acquired thrombophilia characterized by recurrent arterial or venous thrombosis and/or pregnancy morbidity in the presence of autoantibodies against phospholipid (PL)-binding plasma proteins, mainly a plasma apolipoprotein known as  2 glycoprotein I (2GPI) and prothrombin (Table 320-1). Another group of antibodies termed lupus anticoagulant (LA) prolong clotting times in vitro; this prolongation is not corrected by adding normal plasma to the detection system. APS may occur alone (primary), or in association with any other autoimmune disease (secondary). Catastrophic APS (CAPS) is defined as a rapidly progressive thromboembolic disease involving simultaneously three or more organs, organ systems, or tissues leading to corresponding functional defects...."
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