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Harrison's Principles of Internal Medicine, 18e | Part 15. Disorders of the Joints and Adjacent Tissues > Section 2. Disorders of Immune-Mediated Injury > | Chapter 321. Rheumatoid Arthritis Sections: Introduction, Clinical Features, Epidemiology, Genetic Considerations, Environmental Factors, Pathology, Pathogenesis, Diagnosis, Clinical Course, Global Challenges, Summary, Further Readings. Topics Discussed: rheumatoid arthritis. Excerpt:"Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology marked by a symmetric, peripheral polyarthritis. It is the most common form of chronic inflammatory arthritis and often results in joint damage and physical disability. Because it is a systemic disease, RA may result in a variety of extraarticular manifestations, including fatigue, subcutaneous nodules, lung involvement, pericarditis, peripheral neuropathy, vasculitis, and hematologic abnormalities...."
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