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Harrison's Principles of Internal Medicine, 18e | Part 15. Disorders of the Joints and Adjacent Tissues > Section 2. Disorders of Immune-Mediated Injury > | Chapter 322. Acute Rheumatic Fever Sections: Acute Rheumatic Fever: Introduction, Global Considerations, Epidemiology, Pathogenesis, Clinical Features, Prognosis, Prevention, Further Readings. Topics Discussed: acute rheumatic fever. Excerpt:"Acute rheumatic fever (ARF) is a multisystem disease resulting from an autoimmune reaction to infection with group A streptococcus. Although many parts of the body may be affected, almost all of the manifestations resolve completely. The exception is cardiac valvular damage [rheumatic heart disease (RHD)], which may persist after the other features have disappeared...."
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