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Harrison's Principles of Internal Medicine, 18e
| Part 16. Endocrinology and Metabolism > Section 1. Endocrinology > |
Chapter 341. Disorders of the Thyroid Gland
Sections: Disorders of the Thyroid Gland: Introduction, Anatomy and Development, Regulation of the Thyroid Axis, Thyroid Hormone Synthesis, Metabolism, and Action, Hypothyroidism, Thyrotoxicosis, Thyroiditis, Sick Euthyroid Syndrome, Amiodarone Effects on Thyroid Function, Thyroid Function in Pregnancy, Goiter and Nodular Thyroid Disease, Benign Neoplasms, Thyroid Cancer, Further Readings.
Topics Discussed: thyroid disorders.
Excerpt:"The thyroid gland produces two related hormones, thyroxine (T4) and triiodothyronine (T3) (Fig. 341-1). Acting through thyroid hormone receptors  and  , these hormones play a critical role in cell differentiation during development and help maintain thermogenic and metabolic homeostasis in the adult. Autoimmune disorders of the thyroid gland can stimulate overproduction of thyroid hormones (thyrotoxicosis) or cause glandular destruction and hormone deficiency (hypothyroidism). In addition, benign nodules and various forms of thyroid cancer are relatively common and amenable to detection by physical examination...."
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