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Harrison's Principles of Internal Medicine, 18e
| Part 16. Endocrinology and Metabolism > Section 1. Endocrinology > |
Chapter 344. Diabetes Mellitus
Sections: Diabetes Mellitus: Introduction, Classification, Epidemiology, Diagnosis, Insulin Biosynthesis, Secretion, and Action, Pathogenesis, Genetically Defined, Monogenic Forms of Diabetes Mellitus, Acute Complications of DM, Chronic Complications of DM, Long-Term Treatment, Complications of Therapy for Diabetes Mellitus, Ongoing Aspects of Comprehensive Diabetes Care, Special Considerations in Diabetes Mellitus, Further Readings.
Topics Discussed: diabetes mellitus.
Excerpt:"Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Several distinct types of DM are caused by a complex interaction of genetics and environmental factors. Depending on the etiology of the DM, factors contributing to hyperglycemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production. The metabolic dysregulation associated with DM causes secondary pathophysiologic changes in multiple organ systems that impose a tremendous burden on the individual with diabetes and on the health care system. In the United States, DM is the leading cause of end-stage renal disease (ESRD), nontraumatic lower extremity amputations, and adult blindness. It also predisposes to cardiovascular diseases. With an increasing incidence worldwide, DM will be a leading cause of morbidity and mortality for the foreseeable future...."
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